A PHYSIOLOGICALLY BASED PHARMACOKINETIC FRAMEWORK FOR QUANTIFYING ANTIBODY DISTRIBUTION GRADIENTS FROM TUMORS TO TUMOR-DRAINING LYMPH NODES

A Physiologically Based Pharmacokinetic Framework for Quantifying Antibody Distribution Gradients from Tumors to Tumor-Draining Lymph Nodes

Immune checkpoint blockades prescribed in the neoadjuvant setting are now under active investigation for many types of tumors, and many have shown early success.The primary tumor (PT) and Candida tumor-draining lymph node (TDLN) immune factors, along with adequate therapeutic antibody distributions to the PT and TDLN, are critical for optimal immun

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A Duplicated Copy of the Meiotic Gene ZIP4 Preserves up to 50% Pollen Viability and Grain Number in Polyploid Wheat

Although most flowering plants are Vintage Strap polyploid, little is known of how the meiotic process evolves after polyploidisation to stabilise and preserve fertility.On wheat polyploidisation, the major meiotic gene ZIP4 on chromosome 3B duplicated onto 5B and diverged (TaZIP4-B2).TaZIP4-B2 was recently shown to promote homologous pairing, syna

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